We see a lot of crazy stuff on scientific posters, and using goofy fonts is certainly one of them. While it’s a lot of fun to use a wild type face, you need to be careful that it doesn’t get in the way of making your poster easy to read and understand.
Conventional graphic design wisdom dictates the use of sans-serif fonts (such as Arial) for titles and headlines, and serif fonts (the ones with the pointy ends like Times New Roman) in paragraphs. The little pointy ends of serif fonts guide your eye along, and make reading easier. These rules have withstood the test of time, and I encourage you to follow them.
There’s also the simple fact that a goofy font makes your poster less serious. I can give you the experience of my brother, who tells me that he goes to poster sessions to find talent. You don’t want a goofy poster hanging up when the VP of Research from a top biotech stops by.